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KMID : 0900220190260020106
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대한비과학회지
2019 Volume.26 No. 2 p.106 ~ p.112
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The Effects of Olfactory Training with Intranasal Corticosteroid Spray in Korean Patients with Olfactory Dysfunction
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Jung Young-Do
Kim Deok-Su
Kang Byung-Jun
Shin Seung-Heon
Ye Mi-Kyung
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Abstract
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Background and Objectives: Olfactory training is an alternative treatment based on modulation of the regeneration processof the olfactory system via repeated exposure to odors. Our study aimed to investigate the impact of olfactory training with intranasalcorticosteroid in Korean patients with various causes of olfactory dysfunction.
Subjects and Method: Our study population comprised 134 adults with olfactory dysfunction of different etiologies (postviralinfection n=85; post-traumatic n=18; and idiopathic n=31). For training, patients exposed themselves to four different odorstwice a day. All patients used fluticasone nasal spray (two sprays in each nostril once daily). Olfactory function was evaluated atbaseline and again at three months, and results were quantified as patient TDI (threshold, discrimination, and identification) score.
Results: Olfactory function improved in 74 of 134 patients (55.2%). Etiology of olfactory disorder, sex, and age had statisticallysignificant influence on the improvement rate of olfactory function, among which etiology of olfactory loss was the most important. However, initial severity and duration of olfactory loss had no statistically significant influence on the improvement rate. The TDI score at three months of olfactory training showed remarkable improvement, primarily because of improvements in thediscrimination and identification components.
Conclusion: The present study showed that olfactory training with intranasal corticosteroid was beneficial to improve olfactoryfunction in patients with olfactory dysfunction, particularly in postviral infection patients.
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KEYWORD
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Olfaction disorders, Postviral, Post-traumatic, Olfactory training
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